Motor carriers must ensure and verify that their CMV drivers meet the minimum requirements specified in 49 CFR 391 before operating a vehicle. CMV owner–operators must comply with both rules that apply to motor carriers and rules that apply to drivers. An owner–operator is a person who operates a CMV under his or her own authority (U.S. DOT Number), as both a motor carrier and self-employed driver.
To drive a CMV in interstate commerce, drivers must comply with the general qualifications outlined in 49 CFR 391.11, including:
- Be at least 21 years of age.
 - Speak and read English satisfactorily to:
- Converse with the general public;
 - Understand traffic signs and signals;
 - Respond to official questions; and
 - Make legible entries on reports and records.
 
 - Drive the vehicle safely.
 - Be physically qualified to perform all duties of a driver.
 - Have only one valid commercial motor vehicle operator’s license issued by one State or jurisdiction.
 - Pass a driver’s road test or equivalent.
 -  Is     not disqualified to drive a commercial motor vehicle under the rules in 49     CFR 391.15.
 
A disqualified driver must not drive a commercial motor vehicle for any reason. See 49 CFR 391.15.