Certain motor carriers (interstate or intrastate) must have a hazardous materials safety permit to transport high-hazard materials by highway. Check the FMCSA Safety Permit Program to find out if a carrier needs a hazardous materials safety permit and requirements for obtaining and maintaining a safety permit. The Federal Hazardous Materials Regulations (HMRs) (49 CFR 100-180) are applicable to intrastate, interstate, and international transportation. FMCSA enforces the HMRs as they apply to highway transportation.